Objective To compare the effects of Meek skin grafting and stamp skin grafting on scar hyperplasia and joint function recovery in patients with extensive deep burns. Methods A total of 48 patients with extensive deep burns admitted to the First Affiliated Hospital of Anhui Medical University from October 2024 to October 2025 were selected as the research subjects. According to the random number table method, they were divided into the control group and the observation group, with 24 patients in each group. The control group received conventional stamp skin grafting, and the observation group received Meek skin grafting. The scar hyperplasia, joint function recovery, inflammatory factor levels, quality of wound repair and medical resource efficiency indicators were compared between the two groups. Results At 3 months after operation, the degree of scar hyperplasia and the recovery of joint function in the observation group were better than those in the control group (P <0.05). The peak serum concentrations of IL-6 and TNF-α in the observation group at postoperative day 7 were lower than those in the control group (P <0.05). The time for complete wound epithelialization in the observation group was shorter than that in the control group, the survival rate of skin grafts was higher than that in the control group, and the incidence of wound infection was lower than that in the control group (P <0.05). The skin removal area of single operation in the observation group was smaller than that in the control group, and the total operation time and hospitalization time were shorter than those in the control group (P <0.05). Conclusion For patients with extensive deep burns, Meek skin grafting can alleviate scar hyperplasia, promote joint function recovery, regulate inflammatory factor levels, improve wound repair quality, and optimize medical resource efficiency.