Microfocused ultrasound (MFU) is a widely used non-invasive facial anti-aging modality in clinical practice. It focuses ultrasonic energy on the dermis and superficial musculoaponeurotic system (SMAS), which induces immediate contraction of collagen fibers and long-term remodeling effects. As the demand for facial rejuvenation shifts from single tightening and lifting to multi-level comprehensive improvement, the combined application of MFU with injectable therapies such as botulinum toxin and hyaluronic acid, as well as photoelectric technologies including radiofrequency, laser and intense pulsed light, has gradually increased. Existing studies suggest that different combined regimens have certain advantages in improving wrinkles, laxity, skin texture and patient satisfaction. However, the relevant evidence is still mainly based on single-center, small-sample and short-term follow-up studies. Great variations exist in efficacy evaluation indicators and treatment protocols, which limits the comparability and extrapolation of research findings. It is still difficult to form unified and reproducible clinical pathways regarding the suitable population, treatment sequence, time interval and energy parameters for combined therapy. This paper reviews the mechanism, clinical efficacy, safety and research progress of combined therapy of MFU, so as to provide references for its standardized clinical application.