Objective To explore the effect of skin nursing education combined with humanized nursing on acne severity and skin lesions in patients with acne. Methods A total of 60 patients with acne admitted to Guangzhou Dermatology Hospital from March 2024 to March 2025 were selected. According to the outpatient sequence, they were divided into the control group and the observation group based on random number table method, with 30 patients in each group. The control group was given conventional nursing, and the observation group was additionally given skin nursing education combined with humanized nursing on the basis of the control group. The acne severity, skin lesions, psychological status and disease awareness were compared between the two groups. Results After intervention, the GAGS score of the observation group was lower than that of the control group (P<0.05). After intervention, the scores of skin lesion color, lesion property and lesion swelling and pain in the observation group were lower than those in the control group (P<0.05). After intervention, the scores of SAS and SDS in the observation group were lower than those in the control group (P<0.05). After intervention, the scores of disease awareness in the observation group were higher than those in the control group (P <0.05). Conclusion The application of skin nursing education combined with humanized nursing in patients with acne has a good effect. It can effectively reduce acne severity, reduce skin lesions, help to improve patients' anxiety and depression, and enhance their disease awareness.