Objective: To evaluate the effects of concentrated growth factor (CGF) versus topical minoxidil with microneedling on quality of life and psychological status in androgenetic alopecia (AGA) patients post-hair transplantation.Methods: 80 AGA patients undergoing hair transplantation were prospectively randomized into Group A (CGF, n=40) and Group B (minoxidil+microneedling, n=40). SF-36, DASS-21, SWLS, and MSPSS were assessed at baseline, and 1, 3, and 6 months postoperatively.Results: Both groups significantly improved at 6 months (P<0.05). Group A showed faster psychological benefits, outperforming Group B in mental health (MCS), negative emotions, and life satisfaction at 1 month (P<0.05). Conversely, Group B achieved better physical health (PCS) recovery at 6 months, with a higher MCID response rate (P=0.002). Mental health consistently correlated positively with perceived social support (P<0.01).Conclusion: Both interventions effectively improve AGA patients" quality of life. CGF offers rapid early psychological benefits, while minoxidil with microneedling provides superior long-term physical recovery.