Objective To explore the practical effect of clinical clerkship teaching model based on the three-dimensional integration of "clinical thinking-practical skills-humanistic care" in burn department. Methods A total of 70 clerks from the Afffliated Hospital of Guizhou Medical University from January to December 2025 were selected, and they were divided into the control group and the study group by the random number table method, with 35 clerks in each group. The control group received the traditional teaching model, and the study group received the clinical clerkship teaching model based on the three-dimensional integration of "clinical thinking-practical skills-humanistic care" in burn department. The assessment scores, clinical thinking scores, humanistic care ability scores and teaching satisfaction were compared between the two groups. Results The scores of theoretical assessment, practical assessment and total score in the study group were higher than those in the control group (P<0.05). The scores of all dimensions of clinical thinking in the study group were higher than those in the control group (P<0.05). The scores of all dimensions of humanistic care in the study group were higher than those in the control group (P<0.05). The teaching satisfaction of the study group (94.29%) was higher than that of the control group (74.29%) (P<0.05). Conclusion The application of the clinical clerkship teaching model based on the three-dimensional integration of "clinical thinking-practical skills-humanistic care" in burn department has a good practical effect. It can improve students' assessment scores, effectively enhance their clinical thinking andpractical skills, strengthen their humanistic care literacy, and achieve high teaching satisfaction, with deffnite application value.