Objective To investigate the application effect of pediatric nursing project in medical adhesive related skin injury (MARSI) in children. Methods A total of 70 children with MARSI admitted to the Department of Pediatrics, Dongtai People’s Hospital from October 2023 to October 2025 were selected as the research subjects. According to the random number table method, they were divided into the control group and the study group, with 35 children in each group. The control group received conventional nursing, and the study group received pediatric nursing project on the basis of the control group. The clinical symptom scores, MARSI prevention knowledge and behavior scores among nurses, MARSI rate, satisfaction of parents and self-rated satisfaction of nurses were compared between the two groups. Results The scores of skin injury and pain in the study group were lower than those in the control group (P<0.05). The MARSI prevention knowledge and behavior scores and total scores among nurses in the study group were higher than those in the control group (P<0.05). The incidence of MARSI in the study group was lower than that in the control group (P<0.05). The parental satisfaction in the study group (97.14%) was higher than that in the control group (80.00%) (P<0.05). The self-rated satisfaction of nurses in the study group was higher than that in the control group (P<0.05). Conclusion Pediatric nursing project can effectively prevent and reduce the incidence of MARSI in children, improve the awareness rate of MARSI prevention knowledge among nurses and the satisfaction of parents and nurses, which is worthy of clinical application.