Objective To investigate the effect of medical moisturizing repair agents combined with topical glucocorticoid on eczema severity and pruritus degree in patients with eczema. Methods A total of 128 patients with eczema admitted to Zengcheng District Xintang Central Health Center from January 2023 to January 2025 were selected. According to the random number table method, they were divided into the control group and the observation group, with 64 patients in each group. The control group was treated with topical glucocorticoid, and the observation group was treated with medical moisturizing repair agent combined with topical glucocorticoid. The eczema severity, pruritus degree, transepidermal water loss (TEWL) and adverse reaction rate were compared between the two groups. Results After 4 weeks of treatment, the score of EASI in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05). After 4 weeks of treatment, the score of NRS in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05). After 4 weeks of treatment, the TEWL in the two groups was lower than that before treatment, and that in the observation group was lower than that in the control group (P<0.05). There was no signiffcant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The application of medical moisturizing repair agent combined with topical glucocorticoid is effective in the treatment of patients with eczema, which can effectively alleviatee eczema severity and pruritus symptoms, and help to improve skin barrier function, without increasing the risk of adverse reactions. It has deffnite clinical application value.