Objective To investigate the application effect of Meisu ENA HRi esthetic restoration system in the restoration of class Ⅳ cavities of anterior teeth. Methods A total of 60 patients with class Ⅳ cavities of anterior teeth admitted to our hospital from January 2024 to January 2025 were selected, and they were divided into the reference group and the study group by the random number table method, with 30 patients in each group. The reference group was treated with light-sensitive composite resin, and the study group was treated with Meisu ENA HRi esthetic restoration system. The color matching, restoration quality score, anatomical morphological recovery, marginal adaptation score and adverse event rate were compared between the two groups. Results The color matching score in the study group was higher than that in the reference group, and the difference was statistically signiffcant (P<0.05). The restoration quality scores in the study group immediately after restoration and at 3 months after restoration were higher than those in the reference group, and the differences were statistically significant (P<0.05). The scores of anatomical morphology recovery and marginal adaptation in the study group were higher than those in the reference group, and the differences were statistically signiffcant (P<0.05). The incidence of adverse events in the study group was lower than that in the reference group, and the difference was statistically signiffcant (P<0.05). Conclusion The application of Meisu ENA HRi esthetic restoration system in the restoration of class Ⅳ cavities of anterior teeth shows excellent color matching, which can effectively improve restoration quality score, anatomical morphology recovery and marginal adaptation score, and reduce the incidence of adverse events.