Objective To investigate the effect of concentrated growth factor (CGF)-based guided bone regeneration (GBR) on peri-implant soft and hard tissues. Methods A total of 60 patients with insufffcient bone mass and gingival defect in posterior implant areas treated at the Seventh Afffliated Hospital of Xinjiang Medical University from October 2023 to October 2024 were selected, and they were divided into the control group and the observation group by the random number table method, with 30 patients in each group. Both groups received implant placement. The control group received GBR, and the observation group received CGF combined with GBR. The pain intensity, implant survival rate, mucosal healing, bone thickness, bone tissue repair effect and keratinized gingival width were compared between the two groups. Results The VAS score in the observation group at 24 h after operation was lower than that in the control group, but the difference was not statistically signiffcant (P>0.05). There was no signiffcant difference in implant survival rate between the two groups at 6 months after operation (P>0.05). The excellent and good rate of mucosal healing in the observation group (100.00%) was higher than that in the control group (90.00%), but the difference was not statistically signiffcant (P>0.05). The horizontal and vertical bone mass around implants in the observation group at 6 and 12 months after operation were higher than those in the control group (P<0.05). There were no signiffcant difference in the excellent and good rates of bone tissue repair between two groups at 6, 9 and 12 months after operation (P>0.05). The keratinized gingival width in the observation group at 6 and 12 months after operation was higher than that in the control group (P<0.05). Conclusion The application of CGF combined with GBR in implant restoration for insufffcient bone mass and gingival defect in posterior areas can effectively improve osteogenic capacity and soft tissue regeneration, and optimize the conditions of peri-implant soft and hard tissues.