Objective To analyze the effect of digital denture duplication technology in complete denture restoration for patients with severe and uneven alveolar bone resorption. Methods A total of 80 patients with severe and uneven alveolar bone resorption admitted to Yinchuan Stomatology Hospital from October 2024 to October 2025 were selected as the research subjects. According to the random number table method, they were divided into the control group and the observation group, with 40 patients in each group. The control group received traditional complete denture restoration, and the observation group received restoration with digital denture duplication technology. The restoration effect, craniomandibular index (CMI), impression time, total grinding times, oral comfort and aesthetic effect were compared between the two groups. Results The scores of oral restoration adhesion, restoration shape and restoration color in the observation group were higher than those in the control group (P<0.05). The CMI score of the two groups at 3 months after restoration was lower than that before treatment, and that of the observation group was lower than that of the control group (P<0.05). The impression time and total grinding times in the observation group were less than those in the control group, and the oral comfort score was higher than that in the control group (P<0.05). The proportions of neat tooth arrangement, good anterior teeth coverage and occlusion, and good posterior teeth occlusion in the observation group were higher than those in the control group (P<0.05). Conclusion The application of digital denture duplication technology in complete denture restoration for patients with severe and uneven alveolar bone resorption can improve the restoration effect, reducetemporomandibular joint disorders, shorten the impression time, reduce the total grinding times, help to improve the oral comfort of patients, and achieve ideal aesthetic effect. It is worthy of clinical application.