Objective To investigate the effect of adsorptive denture restoration on oral health impact profile in completely edentulous patients. Methods A total of 73 completely edentulous patients admitted to our hospital from January 2022 to December 2025 were selected and, they were divided into the control group (n=36) and the observation group (n=37) by the random number table method. The control group received traditional complete denture restoration, and the observation group received adsorptive denture restoration. The oral health impact profile, satisfaction and complication rate were compared between the two groups. Results After restoration, the scores of all dimensions of OHIP-14 in the two groups were lower than those before restoration, and those in the observation group were lower than those in the control group (P<0.05). The scores of all dimensions of satisfaction in the observation group were higher than those in the control group (P<0.05). The incidence of complications in the observation group (24.32%) was lower than that in the control group (47.22%) (P<0.05). Conclusion Adsorptive denture restoration for completely edentulous patients can effectively reduce oral health impact, improve restoration satisfaction, and help to reduce the risk of postoperative complications, with deffnite clinical application value.