Objective To investigate the application effect of precision nursing in reconstruction of severe bone defects in anterior region with 3D-printed individualized titanium mesh. Methods A total of 50 patients who underwent restoration of severe bone defects in the anterior region at Afffliated Stomatological Hospital of Xuzhou Medical University from March 2023 to March 2025 were selected as the research subjects. According to the random number table method, they were divided into the control group and the experimental group, with 25 patients in each group. The control group received conventional nursing, and the experimental group received precision nursing. The new bone augmentation, soft tissue aesthetic effect, quality of life, satisfaction, complication rate and nursing compliance were compared between the two groups. Results After nursing, the horizontal bone augmentation, vertical bone augmentation and bone augmentation volume in the experimental group were better than those in the control group (P<0.05). The PES score in the experimental group after nursing was higher than that in the control group (P<0.05). The OHIP-14 score in the experimental group after nursing was lower than that in the control group (P<0.05). The satisfaction score in the experimental group after nursing was better than that in the control group (P<0.05). The early exposure rate of titanium mesh in the experimental group after nursing was lower than that in the control group (P<0.05). The follow-up and treatment plan compliance in the experimental group after nursing were better than those in the control group (P<0.05). Conclusion The application of precision nursing helps to improve the new bone augmentation in reconstruction of severe bone defects in anterior region with 3D-printed individualized titanium mesh, enhance patients' quality of life and aesthetic effect, and reduce the incidence of complications.