Objective To investigate the effect of targeted nursing on periodontal health status in patients with dentin hypersensitivity after aesthetic restoration of anterior teeth with resin. Methods A total of 100 patients who developed dentin hypersensitivity after aesthetic restoration of anterior teeth with resin at the First Outpatient Department of Yinchuan Stomatology Hospital from June 2023 to June 2025 were selected as the research subjects. According to the random number table method, they were divided into the reference group and the study group, with 50 patients in each group. The reference group received conventional oral nursing, and the study group received targeted nursing. The pain status, periodontal health status, remission time of hypersensitivity symptoms and nursing satisfaction were compared between the two groups. Results The pain score in the study group after nursing was lower than that in the reference group (P<0.05). The gingival index score and periodontal probing depth in the study group after nursing were lower than those in the reference group (P<0.05). The remission time of hypersensitivity symptoms in the study group was shorter than that in the reference group (P<0.05). The nursing satisfaction rate in the study group (96.00%) was higher than that in the reference group (80.00%) (P<0.05). Conclusion Targeted nursing can effectively shorten the remission time of hypersensitivity symptoms in patients after aesthetic restoration of anterior teeth with resin. It also relieves pain, improves periodontal health, and enhances nursing satisfaction.