Objective To analyze the effect of orthodontics combined with implant restoration on masticatory function and aesthetic effect in patients with dentition defect complicated by malocclusion. Methods A total of 80 patients with dentition defect complicated by malocclusion admitted to Huichuan Guangming Mingchi Dental Clinic from March 2023 to January 2025 were selected. According to different treatment methods, they were divided into the reference group and the observation group, with 40 patients in each group. The reference group received implant restoration, and the observation group received orthodontics combined with implant restoration. The masticatory function, aesthetic effect, periodontal health status and quality of life were compared between the two groups. Results After 6 months of treatment, the masticatory efffciency and occlusal force in the observation group were higher than those in the reference group (P<0.05). After 6 months of treatment, the pink esthetic score and white esthetic score in the observation group were higher than those in the reference group (P<0.05). After 12 months of treatment, the PLI, GI and SBI in the observation group were lower than those in the reference group (P<0.05). After 12 months of treatment, the quality of life score in the observation group was higher than that in the reference group (P<0.05). Conclusion The application of orthodontics combined with implant restoration in the treatment of dentition defect complicated by malocclusion can improve periodontal health status, effectively enhance occlusal force and aesthetic effect, and promote quality of life.