【Abstract】Objective To investigate the difference in therapeutic efficacy of multimodal intervention initiated at different time windows for surgical incision scars, and to identify the optimal intervention timing.?Methods?A total of 100 patients with facial and neck surgical incisions admitted to the Affiliated Guangdong Second Provincial General Hospital of Jinan University from February 2024 to March 2026 were selected and divided into Group W1 (intervention at 1 week after suture removal) and Group M1 (intervention at 1 month after suture removal) according to treatment timing, with 50 cases in each group. Both groups received ultra-pulsed CO? fractional laser combined with mechanical tension reduction and silicone gel therapy. Scar width and thickness, Vancouver Scar Scale (VSS) score, Patient and Observer Scar Assessment Scale (POSAS) score, patient satisfaction, and incidence of adverse reactions were compared between the two groups at 1 month post-treatment.Results The scar width (1.32±0.20 mm) and thickness (1.57±0.29 mm) in Group W1 were significantly lower than those in Group M1 (1.95±0.34 mm, 2.31±0.40 mm) (P＜0.001). The VSS score of Group W1 was 2.08±0.49, obviously lower than 3.48±0.68 of Group M1 (P＜0.001). The proportion of patients with POSAS improvement ≥1 grade was 84.00% in Group W1, 42.00 percentage points higher than 42.00% in Group M1 (P＜0.01). The total patient satisfaction rate was 92.00% in Group W1 versus 72.00% in Group M1 (P＜0.05). The incidence of adverse reactions was 6.00% in Group W1 and 12.00% in Group M1, without statistical difference between two groups (P＞0.05).Conclusion Multimodal intervention at W1 time window (1 week after suture removal) achieves superior therapeutic effect compared with intervention at M1 time window (1 month after suture removal), which is the critical node for early prevention and treatment of facial and neck surgical incision scars.