Acne, as a common dermatological disease, has a high incidence among adolescents and young adults. It not only impairs the skin health of patients, but also may exert negative impacts on their psychological state. In recent years, with the continuous development of medical research, the potential correlation between acne and depression has become a research hotspot. This paper systematically sorts out the existing research results, deeply analyzes the inffuencing factors of the correlation between acne and depressive state and clinical countermeasures, discusses the key directions of future research aiming at the deffciencies of current studies, so as to provide practical references for clinical diagnosis and treatment.