Objective To analyze the effect of four-handed nursing in light-curing resin veneer treatment for patients with dental ffuorosis. Methods A total of 70 patients with dental ffuorosis treated in the Department of Stomatology, China-Japan Friendship Hospital from October 2022 to October 2025 were selected. According to the random number table method, they were divided into the control group and the observation group, with 35 patients in each group. The control group received conventional light-curing resin veneer nursing, and the observation group received four-handed nursing on the basis of the control group. The intervention effect, restoration aesthetics, negative emotions, resin detachment rate and satisfaction were compared between the two groups. Results The total effective rate of the observation group (97.14%) was higher than that of the control group (71.43%) (P<0.05). The excellent and good rate of restoration aesthetics in the observation group (94.29%) was higher than that in the control group (68.57%) (P<0.05). The scores of HAMA and HAMD in the two groups after nursing were lower than those before nursing, and those in the observation group were lower than those in the control group (P<0.05). The resin detachment rate in the observation group (5.71%) was lower than that in the control group (31.43%) (P<0.05). The satisfaction rate of the observation group (94.29%) was higher than that of the control group (65.71%) (P<0.05). Conclusion Four-handed nursing in light-curing resin veneer treatment for patients with dental ffuorosis can effectively improve the intervention effect and restoration aesthetics, reduce the resin detachment rate, alleviate negative emotions of patients, and has positive signiffcance for improving patient satisfaction.