Objective To investigate the effect of nano-silver burn dressing in the treatment of small-area superffcial second-degree burn wound. Methods A total of 74 patients with small-area superffcial second-degree burn who were treated in the outpatient clinic of Department of Burn and Wound Repair Surgery, the First Affiliated Hospital of Anhui Medical University from June 2023 to October 2025 were selected. According to the random number table method, they were divided into the control group and the experimental group, with 37 patients in each group. The control group received routine burn outpatient dressing change, and the experimental group received dressing change with nano-silver burn dressing. The rehabilitation indicators, scar status, pain intensity and complication rate were compared between the two groups. Results The wound healing time and wound pigmentation regression time in the experimental group were shorter than those in the control group (P<0.05). The VSS scores and total score in the experimental group were lower than those in the control group (P<0.05). The VAS scores on the 1st, 2nd, 3rd, 4th, 5th and 7th day of treatment in the experimental group were lower than those in the control group (P<0.05). The incidence of complications in the experimental group (0) was lower than that in the control group (13.51%) (P<0.05). Conclusion The application of nano-silver burn dressing in the treatment of small-area superffcial second-degree burn wound can accelerate wound rehabilitation, promote wound healing and pigmentation regression, reduce scar formation, help to lower the risk of complications and relieve early pain, with deffnite clinical application value.