Sj?gren's syndrome (SS) is an autoimmune disease characterized by damage to the function of exocrine glands, often causing typical symptoms such as dry mouth and dry eyes. Moreover, most patients are prone to developing refractory and progressive generalized skin dryness. The pathology of skin dryness includes dysfunction of sweat glands and sebaceous glands, as well as damage to the skin barrier function, which affects patients' health status. Currently, the clinical treatment for SS-related skin dryness adopts a combined medical aesthetic therapy of compound alpha hydroxy acid (AHA) peeling combined with hydrodermabrasion injection, which has great potential in alleviating patients' skin dryness symptoms and is expected to become an efficient and safe treatment strategy. This article reviews relevant literature from both domestic and international sources, analyzes the individual and synergistic mechanisms of different therapies, and provides a scientific theoretical reference for the promotion and application of treatment strategies. Additionally, by analyzing the adverse reactions of treatment methods, it aims to provide a highly effective and safe adjuvant treatment strategy for the clinic, thereby improving the quality of life for patients with SS-related skin dryness.