Objective To explore the application effect of humanistic care psychological nursing in patients with dentition loss undergoing immediate implantation. Methods A total of 70 patients with dentition loss who received immediate implantation at China-Japan Friendship Hospital from April 2022 to February 2025 were selected as the research subjects. According to the random number table method, they were divided into the traditional group and the humanistic group, with 35 patients in each group. The traditional group received conventional nursing, and the humanistic group received humanistic care psychological nursing on the basis of the traditional group's nursing. The pain status, psychological status and complication rate were compared between the two groups. Results The VAS score of the humanistic group after nursing was lower than that of the traditional group (P<0.05). The scores of SAS and SDS in the humanistic group after nursing were lower than those in the traditional group (P<0.05). The incidence of complications in the humanistic group (5.71%) was lower than that in the traditional group (25.71%) (P<0.05). Conclusion The application of humanistic care psychological nursing in patients with dentition loss undergoing immediate implantation can not only effectively relieve their anxiety and depression, but also reduce pain and help to lower the incidence of complications.