Objective: To investigate the effects of Bepotastine Besilate Tablets combined with Compound Glycyrrhizin Tablets on skin barrier function repair and aesthetic improvement in patients with eczema.Methods: A total of 90 patients with eczema admitted to our hospital from October 2023 to July 2025 were selected and randomly divided into an observation group and a control group, with 45 cases in each group. The control group received oral bepotastine besilate tablets, while the observation group received additional compound glycyrrhizin tablets on the basis of the control group. Both groups were treated continuously for 7 days. The following parameters were compared before and after treatment: transepidermal water loss (TEWL), stratum corneum water content, eczema area and severity index (EASI) score, melanin index (MI), erythema index (EI), serum total IgE, and eosinophil count (EOS).Results: Before treatment, there were no significant differences between the two groups in TEWL, EASI score, MI, EI, serum total IgE, EOS, and stratum corneum water content (P>0.05). After treatment, the observation group showed significantly lower TEWL, EASI score, MI, EI, serum total IgE, and EOS levels compared to the control group (P<0.05), while the stratum corneum water content was significantly higher than that in the control group (P<0.05).Conclusion: BBepotastine besilate tablets combined with compound glycyrrhizin tablets can more effectively repair the skin barrier function, reduce inflammatory response, and improve skin aesthetic appearance in patients with eczema, and its effect is superior to bepotastine besilate tablets alone.