Objective: To explore the application effect of a minimally invasive aesthetic nursing model based on facial anatomical partitioning in patients undergoing skin tumor excision. Methods: A total of 90 patients who underwent facial skin tumor excision in our hospital from November 2022 to December 2024 were selected and randomly divided into two groups, with 45 cases in each group. The control group received conventional nursing, while the observation group was provided with a minimally invasive aesthetic nursing model based on facial anatomical partitioning. Results: The postoperative scar scores in the observation group were lower than those in the control group. The overall complication rate was 4.44%, lower than the control group"s 17.78% (P<0.05); the nursing satisfaction scores of the patients in the observation group were higher than those in the control group (P<0.05). Conclusion: Applying a minimally invasive aesthetic nursing model based on facial anatomical partitioning in patients undergoing facial skin tumor excision can effectively improve scar healing, reduce the incidence of complications, and improve patient nursing satisfaction, demonstrating high clinical promotion value.