Objective To analyze the effect of oral implant restoration on oral function and levels of inflammatory factors in gingival crevicular ffuid in patients with dentition defect. Methods A total of 40 patients with dentition defect admitted to Jinping County People's Hospital from January 2023 to December 2025 were selected, and they were divided into the control group and the observation group according to different restoration methods, with 20 patients in each group. The control group received conventional restoration, and the observation group received oral implant restoration. The oral function, levels of inffammatory factors in gingival crevicular ffuid, gingival indexes and oral health status were compared between the two groups. Results After intervention, the scores of masticatory function, language function and fixation function in the observation group were higher than those in the control group (P<0.05). After intervention, the levels of IFN-γ and IL-8 in the observation group were lower than those in the control group, and the level of ALP was higher than that in the control group (P<0.05). After intervention, the plaque index and periodontal pocket depth in the observation group were lower than those in the control group (P<0.05). After intervention, the scores of all dimensions of OHIP-14 in the observation group were lower than those in the control group (P<0.05). Conclusion Oral implant restoration in patients with dentition defect can effectively improve their oral function, reduce the levels of inffammatory factors in gingival crevicular ffuid, and is conducive to optimizing the gingival indexes and oral health status.