Objective To analyze the effect of bracketless invisible orthodontics combined with implant restoration on masticatory function in patients with Angle Class Ⅲ malocclusion complicated by dentition defect. Methods A total of 76 patients with Angle Class Ⅲ malocclusion complicated by dentition defect admitted to our hospital from January 2023 to December 2024 were selected, and they were divided into the control group and the observation group by the random number table method, with 38 patients in each group. The control group was treated with implant restoration, and the observation group was treated with bracketless invisible orthodontics combined with implant restoration. The clinical efficacy, masticatory function and aesthetic effect were compared between the two groups. Results The excellent and good rate of treatment in the observation group (94.74%) was higher than that in the control group (78.95%) (P<0.05). The occlusal force and masticatory efffciency of the observation group after treatment were higher than those of the control group (P<0.05). The scores of each dimension of PES and crown morphology score in the observation group were higher than those in the control group (P<0.05). There were no statistically signiffcant differences in scores of transparency, crown color, crown surface texture and crown contour between the two groups (P>0.05). Conclusion For patients with Angle Class Ⅲ malocclusion complicated by dentition defect, bracketless invisible orthodontics combined with oral implant restoration has an ideal clinical effect, which can effectively improve masticatory function and aesthetic effect.