Objective:To analyze the clinical efficacy and safety of gold microneedle radiofrequency combined with non-ablative fractional laser in the treatment of facial acne depressed scars. Methods: From January 2024 to June 2025, 120 patients with facial acne depressed scars admitted to our hospital were selected. Using the random number table method, the patients were divided into the observation group (gold microneedle radiofrequency combined with non-ablative fractional laser treatment) and the control group (single non-ablative fractional laser treatment), with 60 cases in each group. The severity of scars (ECCA score), global aesthetic improvement (GAIS score), clinical total effective rate, patient satisfaction, and incidence of adverse reactions were compared between the two groups. Results: After treatment, the ECCA score of the observation group was lower than that of the control group (P < 0.05); the GAIS score of the observation group was better than that of the control group (P < 0.05); the clinical total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05); the patient satisfaction score of the observation group was higher than that of the control group (P < 0.05); there was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion: The use of gold microneedle radiofrequency combined with non-ablative fractional laser in the treatment of facial acne depressed scars can reduce the severity of scars, improve the overall aesthetic effect, increase patient satisfaction, and has good safety. Keywords: Gold Microneedle Radiofrequency; Non-Ablative Fractional Laser; Facial Acne Depressed Scars; Clinical Efficacy