With the increasing demand for facial rejuvenation, non-surgical minimally invasive treatments have become increasingly popular. Botulinum toxin type A (BoNT-A) can effectively improve dynamic wrinkles such as forehead lines, glabellar lines, and crow's feet by blocking the release of neurotransmitters at the neuromuscular junction, but its effect on volume loss, tissue laxity, and overall skin aging is limited. In recent years, it has been commonly combined with hyaluronic acid fillers, platelet-rich plasma with microneedling, autologous fat grafting, fractional laser, thread lifting and other technologies in clinical practice, intervening in aging facial features from multiple aspects including muscle tension regulation, volume reconstruction and skin remodeling. Practice has shown that such combined regimens are superior to single technologies in reducing wrinkles, reshaping facial contours and improving skin texture, and are safe under standardized operation. This paper reviews the application and adverse reaction characteristics of BoNT-A combined with various injection and minimally invasive technologies in facial rejuvenation, evaluates the advantages and limitations of existing evidence based on possible synergistic mechanisms, and brieffy discusses the research directions of standardized combined approaches and individualized strategies, aiming to provide references for optimizing clinical non-surgical facial rejuvenation regimens.