Objective To explore the effect of oral cleaning nursing combined with moisturizing nursing on gingival color uniformity and oral dryness in postpartum women. Methods A total of 120 postpartum women who visited the School of Stomatology, Anhui Medical University (Afffliated Stomatological Hospital) from February 2024 to June 2025 were selected as the research subjects, and they were divided into the basic group and the study group by the random number table method, with 60 women in each group. The basic group received conventional oral nursing, and the study group received oral cleaning nursing combined with moisturizing nursing. The gingival color uniformity, gingival texture, oral dryness and oral comfort were compared between the two groups. Results The scores of gingival color uniformity in the study group at 1 and 3 months after nursing were higher than those in the basic group (P<0.05). The scores of gingival texture in the study group at 1 and 3 months after nursing were higher than those in the basic group (P<0.05). The oral dryness of the study group after nursing was lower than that of the basic group (P<0.05). The scores of oral comfort indicators in the study group after nursing were higher than those in the basic group (P<0.05). Conclusion The application of oral cleaning nursing combined with moisturizing nursing is helpful to improve the uniformity of gingival color and texture of postpartum women, reduce oral dryness, and thus comprehensively enhance oral comfort.