: Objective To investigate the effectiveness of occlusal guidance combined with myofunctional training in the early orthodontic treatment of cren with malocclusion. Methods Sixty children with malocclusion undergoing early orthodontic treatment in our hospital from January 2024 to December 2025 wselected and divided into an observation group (30 cases) and a control group (30 cases) using a random number table. The control group received occlusal guidanceic treatment, while the observation group received additional myofunctional training on the basis of the control group. The treatment duration was 12 months. Changes in tromandibular joint-related angular indices before and after treatment were observed in both groups, along with treatment progress, improvement in chewing function, and treatment satisfaction scores. Results The differences inemporomandibular joint-related angular indices before and after treatment in the observation group were all higher than those in the control group (P<0.05). In the observatioup, the time for space closure (7.26±0.85 months), overbite correction (4.02±0.58 months), leveling andaligning (4.63±0.45 months), and molar movement (4.76±1.02 months) were all shorter than those in the contrl group (P<0.05). After 12 months of treatment, the chewing function score in the observation group (8.36±0.42 points) was highthan that in the control group (7.11±0.51 points) (P<0.05), and the satisfaction scoe (95.26±3.69 points) was also higher than that in the control group (84.25±4.67 points) (P<0.05). Conclusimplementing myofunctional training on the basis of occlusal guidance can improve the treatment effect of malocclusion, accelerate the treatment process, further enhance the children"s chewiunction, and increase overall treatment satisfaction, with good application results.