Objective To analyze the effect of nano-silver dressing combined with moist exposed burn ointment on levels of inffammatory factors and growth factors in patients with second-degree burn. Methods A total of 100 patients with second-degree burn admitted to our hospital from January 2022 to January 2025 were selected, and they were divided into the control group and the study group by the random number table method, with 50 patients in each group. The control group received nano-silver dressing, and the study group received nano-silver dressing combined with moist exposed burn ointment. The wound healing, scar hyperplasia, inffammatory factor levels and growth factor levels were compared between the two groups. Results The wound healing time and complete eschar separation time in the study group were shorter than those in the control group (P<0.05). There was no statistically signiffcant difference in the VSS score between the two groups at the end of treatment (P>0.05). The VSS score in the study group at 3 months of follow-up was lower than that in the control group (P<0.05). At the end of treatment, the serum levels of IL-6 and CRP in the study group were lower than those in the control group (P<0.05). At the end of treatment, the serum levels of VEGF and bFGF in the study group were higher than those in the control group (P<0.05). Conclusion Nano-silver dressing combined with moist exposed burn ointment can synergistically alleviate the early inffammatory response, elevate the levels of wound growth factors, accelerate wound healing, and effectively improve long-term scar hyperplasia in patients with second-degree burn.