Abstract Objective: To systematically evaluate the clinical efficacy and safety of moist exposed burn ointment (MEBO) in promoting postoperative wound repair and cutaneous regeneration after anal fistula surgery, and to provide evidence for the integrated functional and appearance-related repair of postoperative wounds.Methods: PubMed, The Cochrane Library, Embase, Web of Science, Scopus, CINAHL, CNKI, WanFang Data, VIP, and SinoMed were searched to identify randomized controlled trials (RCTs) investigating MEBO for postoperative wounds after anal fistula surgery. Risk of bias was assessed using the RoB 2.0 tool. Meta-analysis was performed using Review Manager 5.4. For the primary outcome, pooled effect estimates with 95% prediction intervals (PIs) were reported, and robustness was further examined using the Hartung-Knapp-Sidik-Jonkman (HKSJ) method. This study was registered in PROSPERO (CRD420251182838).Results: Thirteen RCTs involving 1145 patients were included. Compared with conventional care or standard dressings, MEBO significantly shortened the time to complete wound healing（MD=-6.01 d，95%CI：-7.46~-4.55，P<0.01，95%PI：-11.69~-0.32）and improved cutaneous wound repair progress at postoperative day 14（MD=12.23 percentage points，95%CI：0.50~23.95，P=0.04）.For pain outcomes, the prespecified time window at 1 week(D6–8)showed no significant difference. Pain scores were reduced at 2 weeks(D13–15)（MD=-0.48，95%CI：-0.93~-0.04，P=0.03）. In addition, MEBO improved wound exudate scores at approximately 2 weeks after surgery, alleviated local inflammatory responses, and improved local tissue conditions（SMD=-0.56，95%CI：-0.92~-0.20，P=0.003）.MEBO also increased the overall clinical effectiveness rate（RR=1.53，95%CI：1.13~2.08，P=0.006）,and may reduce the risk of complications（RR=0.18，95%CI：0.03~0.97，P=0.05）.Egger’s test indicated no significant publication bias for the primary outcome(P=0.174). Conclusion: Current evidence suggests that topical MEBO may promote postoperative cutaneous wound repair and re-epithelialization after anal fistula surgery, shorten healing time, and exert beneficial effects on pain relief, exudate control, improvement of local tissue status, and wound repair quality during the early to intermediate postoperative period. However, because of variable methodological quality, substantial heterogeneity, and insufficient reporting of safety outcomes, the overall certainty of the evidence remains limited. The current evidence is therefore insufficient to support routine recommendation of MEBO. High-quality, multicenter RCTs with standardized outcome measures and comprehensive adverse-event reporting are still needed to further clarify its efficacy and safety in wound repair and aesthetic-related healing.