Objective To explore the effect of electric microneedle introduction of minoxidil therapy on alopecia clinical symptom score in patients with alopecia. Methods A total of 60 patients with alopecia admitted to Hangzhou Fuyang District Hospital of Traditional Chinese Medicine from August 2023 to August 2025 were selected as the research subjects, and they were divided into the reference group and the study group by the random number table method, with 30 patients in each group. The reference group received topical minoxidil treatment, and the study group received electric microneedle introduction of minoxidil treatment. The alopecia clinical symptom score, clinical efficacy, hair status and adverse reaction rate were compared between the two groups. Results The alopecia clinical symptom score in the study group after treatment was lower than that in the reference group (P<0.05). The total effective rate of the study group (96.67%) was higher than that of the reference group (73.33%) (P<0.05). The average hair diameter and average hair density of the study group after treatment were better than those of the reference group (P<0.05). There was no statistically signiffcant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The application of electric microneedle introduction of minoxidil can not only effectively improve the treatment effect and reduce the alopecia clinical symptom score in patients with alopecia, but also has high safety, which can promote the recovery of patients' hair status.