Objective To explore the application effect of integrated whole-anesthesia hypothermia prevention strategy in patients undergoing abdominal surgery. Methods A total of 120 patients who underwent abdominal surgery in Suzhou Heiwa Maternity Hospital from June 2023 to June 2025 were selected as the research subjects. According to the random number table method, they were divided into the control group (60 patients) and the observation group (60 patients). The control group received conventional anesthesia temperature management, and the observation group received integrated whole-anesthesia hypothermia prevention strategy. The temperature-related indexes, anesthesia-related adverse reaction rate, incision infection rate and cosmetic satisfaction were compared between the two groups. Results The core temperatures of the observation group at 1 h, 2 h during surgery and at the end of surgery were higher than those of the control group, and the incidence of hypothermia in the observation group (3.33%) was lower than that in the control group (21.67%) (P<0.05). The incidence of anesthesia-related adverse reactions in the observation group was lower than that in the control group (P<0.05). The incidence of postoperative incision infection in the observation group was 5.00%, which was lower than 18.33% in the control group (P<0.05). The cosmetic satisfaction of the observation group was higher than that of the control group (P<0.05). Conclusion The integrated whole-anesthesia hypothermia prevention strategy can effectively maintain the stability of intraoperative temperature in patients undergoing abdominal surgery, reduce the risk of anesthesia-related adverse reactions and the incidence of incision infection, and improve postoperative cosmetic satisfaction.