Objective To analyze the clinical effect of modiffed trefoil ffap technique for nipple reduction mammaplasty in patients with nipple hypertrophy. Methods A total of 40 patients with nipple hypertrophy who underwent nipple reduction mammaplasty in the East Campus of Hebei Yiling Hospital from January 2021 to December 2024 were selected. According to the random number table method, they were divided into the control group and the study group, with 20 patients in each group. The control group was treated with the conventional trefoil ffap technique, and the study group was treated with the modiffed trefoil ffap technique. The breast condition, surgical effect, quality of life, complication rate and surgical satisfaction were compared between the two groups. Results The scores of breast morphology and nipple-areola sensation in the study group were higher than those in the control group, the areola diameter was smaller than that in the control group, and the Scar Cosmesis Assessment and Rating (SCAR) Scale score was lower than that in the control group (P<0.05). The total effective rate of the study group (95.00%) was higher than that of the control group (60.00%) (P<0.05). After intervention, the scores of all dimensions of quality of life in the study group were all higher than those in the control group (P<0.05). The incidence of complications in the study group was lower than that in the control group, and the surgical satisfaction rate was higher than that of the control group (P<0.05). Conclusion The modified trefoil flap technique for nipple reduction mammaplasty exerts a favorable clinical effect in patients with nipple hypertrophy. It can effectively improve breast morphology and nipple-areola sensation, reduce scar formation, decrease areola diameter, enhance the total surgical effective rate, lower the incidence of complications, further optimize the patients' quality of life, and achieve a high level of surgical satisfaction.