Objective To explore the effect of autologous platelet-rich plasma combined with autologous micro-particle skin repair in patients with extensive burn. Methods A total of 40 patients with extensive burn admitted to Huangshi Central Hospital from January 2024 to June 2025 were selected as the research subjects. According to the random number table method, they were divided into group A and group B, with 20 patients in each group. Group A was treated with autologous micro-particle skin repair, and group B was treated with autologous platelet-rich plasma combined with autologous micro-particle skin repair. The scar hyperplasia, wound healing, infection rate and quality of life were compared between the two groups. Results After treatment, the VSS score of group B was lower than that of group A (P<0.05). The wound healing time of group B was shorter than that of group A, and the wound healing rates at 7, 14 and 21 days after treatment were higher than those of group A (P<0.05). The incidence of infection in group B (5.00%) was lower than that in group A (35.00%) (P<0.05). After treatment, the scores of SF-36 in group B were higher than those in group A (P<0.05). Conclusion The combination of autologous platelet-rich plasma and autologous micro-particle skin repair has a deffnite effect in patients with extensive burn. It can effectively alleviate scar hyperplasia, accelerate wound healing, reduce the incidence of infection, and help to improve the quality of life of patients.