Objective: To analyze the effects of pediatric oral comfort treatment on children"s anxiety, pain, and appearance aesthetics. Methods: A mixed cohort design was used, including a prospective cohort (n=50; intervention group) and a retrospective cohort (n=50; control group). The intervention group consisted of children admitted between August 2023 and April 2025, who voluntarily joined the comfortization treatment group with the consent of their guardians; the control group consisted of children randomly selected from the electronic medical record system between August 2023 and April 2025, who were required to have baseline characteristics matching those of the prospective cohort and only received conventional oral treatment. The comfort scores during treatment, anxiety scores before and after treatment, pain scores, appearance aesthetics, and treatment compliance rates of the two groups were compared. Results: The clinical treatment compliance rate of the control group was lower than that of the intervention group during treatment (P<0.05); there were no significant differences in pain scores and smile aesthetics assessment scores between the two groups before treatment (P>0.05); after treatment, the pain scores and smile aesthetics scores of the intervention group were better than those of the control group (P<0.05); the filling detachment rate of the intervention group was lower than that of the control group (P<0.05). Conclusion: By using pediatric oral comfort treatment for oral disease intervention, the discomfort during treatment is reduced, and the treatment compliance of children is improved.