中药面膜联合柴芎祛斑方与维生素C对肝郁血瘀型黄褐斑患者中医证候积分的影响
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1.南京市鼓楼区幕府山社区卫生服务中心;2.江苏省中医院

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Clinical Observation on the Combined Use of Youth-Preserving and Brightening Powder Mask with Oral Medication for the Treatment of Liver Qi Stagnation and Blood Stasis
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    摘要:

    目的 探讨中药面膜联合柴芎祛斑方及维生素C治疗对肝郁血瘀型黄褐斑的临床疗效及对MASI评分的影响。方法 纳入2024年2月至2025年10月于江苏省中医院皮肤科门诊就诊的女性肝郁血瘀型黄褐斑患者70例,采用随机数字表法将其分为对照组和观察组,每组35例。两组患者均予柴芎祛斑方和维生素C片口服,观察组在此基础上加用中药面膜外敷。治疗8周后,比较两组患者的MASI评分、中医证候评分、临床总有效率、DLQI评分及不良反应发生情况。结果 治疗后,两组患者MASI评分均较治疗前显著降低(P<0.05),且观察组低于对照组(P<0.05);观察组临床总有效率为91.43%,高于对照组的71.43%(P<0.05);两组患者中医证候评分、DLQI评分均较治疗前显著下降(P<0.05),且观察组降幅大于对照组(P<0.05);两组不良反应发生率比较,差异无统计学差异(P>0.05)。结论 中药面膜联合柴芎祛斑方及维生素C治疗肝郁血瘀型黄褐斑,可显著改善患者皮损面积、色素沉着程度及均匀度,提高临床疗效及生活质量,且安全性良好。

    Abstract:

    Objective To explore the efficacy of Traditional Chinese Medicine Facial Masks combined with Chai Xiong Spot-Removing Decoction and Vitamin C in the treatment of Liver Qi Stagnation and Blood Stasis Pattern Melasma and its influence on the MASI Scores;Methods Seventy female patients with melasma due to liver qi stagnation and blood stasis who visited the dermatology outpatient clinic at Jiangsu Provincial Hospital of Traditional Chinese Medicine between February 2024 and October 2025 were enrolled and randomly divided into a control group and an observation group, each comprising 35 patients. Both groups of patients received oral administration of Tried and Chai Xiong Spot-Removing Decoction and vitamin C tablets. The observation group additionally applied traditional chinese medicine facial masks topically, in addition to the regimen used in the control group. After 8 weeks of treatment, compare the MASI scores, Traditional Chinese Medicine syndrome scores, overall clinical response rates, DLQI scores, and incidence of adverse reactions between the two groups of patients. Results After treatment, MASI scores decreased significantly in both groups compared with pre-treatment levels (P<0.05), with the observation group showing lower scores than the control group (P<0.05). The clinical total effective rate in the observation group was 91.43%, higher than the 71.43% in the control group (P<0.05). Both groups showed significant reductions in both TCM syndrome scores and DLQI scores compared to pre-treatment levels, with the observation group exhibiting a greater decrease than the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion The combination of traditional chinese medicine facial masks, Chai xiong spot-removing decoction, and vitamin C treatment significantly improves the lesion area, pigmentation intensity, and uniformity in patients with liver-qi stagnation and blood stasis-type melasma. It enhances clinical efficacy and quality of life while demonstrating good safety.

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  • 收稿日期:2026-01-30
  • 最后修改日期:2026-03-16
  • 录用日期:2026-03-17
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