Objective Exploring the in vitro repair effect of collagen combined with ectoine on light-induced skin damage. Methods Based on UVA irradiation damage to fibroblasts, detect changes in the content of type I collagen and type III collagen. Using the 3D epidermal skin model (EpiKutis) ?)perform UVB irradiation damage to detect changes in the levels of inflammatory cytokines (IL-1 α, TNF - α), and inflammatory mediators (PGE2). Results The content of type I and type III collagen in fibroblasts was significantly increased, with increase rates of 92.50% and 100.00%, respectively. The number of sunburn cells significantly decreased based on vitro skin model after UVB irradiation, and the inhibition rate is 73.91%. Inhibit secretion of inflammatory factors (IL-1 α, TNF - α) and inflammatory mediators (PGE2), with inhibition rates of 69.29%, 55.36%, and 52.80%, respectively. Conclusion The combined application of collagen and ectoine has a significant repair effect on skin damage caused by light.