The growing demand for facial rejuvenation has led to increasing use of nonsurgical minimally invasive procedures. Botulinum toxin type A (BoNT-A) improves dynamic wrinkles such as forehead lines, glabellar lines and crow’s feet by blocking neurotransmitter release at the neuromuscular junction, but has limited efficacy for volume loss, tissue laxity and global skin aging. In clinical practice, BoNT-A is frequently combined with other techniques, including hyaluronic acid fillers, platelet-rich plasma (PRP) with microneedling, autologous fat grafting, fractional laser resurfacing and thread lifting, to build multilayer rejuvenation protocols that address muscle tone, volume and skin quality. Available studies suggest that these BoNT-A–based combinations provide better outcomes in wrinkle reduction, contour refinement and skin quality than single-modality treatments, with acceptable safety when performed appropriately. This review summarizes current evidence on BoNT-A combination injectable and minimally invasive techniques for facial rejuvenation, outlines their main indications and outcome measures, and discusses potential synergistic mechanisms, safety considerations and future directions for standardized yet individualized treatment strategies.