Objective To explore the effect of human epidermal growth factor gel combined with moist exposed burn ointment on wound repair in patients with skin burn. Methods A total of 50 patients with skin burn who were treated in Guyuan People's Hospital of Ningxia from June 2023 to June 2025 were selected, and they were divided into the control group and the observation group by the random number table method, with 25 patients in each group. The control group was treated with moist exposed burn ointment, and the observation group was treated with human epidermal growth factor gel combined with moist exposed burn ointment. The wound repair, scar severity, levels of growth factors and inflammatory factors, and adverse reaction rate were compared between the two groups. Results After treatment, the complete wound healing time, exudate regression time, eschar formation time and revascularization time in the observation group were shorter than those in the control group (P <0.05). At 2 months after treatment, the scores of scar thickness, softness and vascular distribution in the observation group were lower than those in the control group (P <0.05). At 2 months after treatment, the levels of bFGF and EGF in the observation group were higher than those in the control group, while the levels of TNF-α and IL-6 were lower than those in the control group (P <0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P >0.05). Conclusion The combined treatment of human epidermal growth factor gel and moist exposed burn ointment has a synergistic effect in the treatment of burn. This regimen can effectively accelerate wound repair, shorten the time of exudate regression, eschar formation andrevascularization, reduce the risk of scar formation by increasing the levels of beneficial growth factors and inhibiting inflammatory response, and has good safety.