Objective To explore the application effect of combined oral myofunctional training and occlusal guidance therapy in early correction of pediatric malocclusion and its influence on aesthetic indicator improvement. Methods A total of 80 patients undergoing early correction of pediatric malocclusion admitted to Huayin People's Hospital from March 2023 to May 2024 were selected as the research subjects, and they were divided into the control group and the observation group by the random number table method, with 40 children in each group. The control group was given traditional fixed appliance, and the observation group was given combined oral myofunctional training and occlusal guidance therapy. The treatment effect, aesthetic indicator improvement and oral myofunction were compared between the two groups. Results The total effective rate of the observation group was 95.00%, which was higher than 77.50% of the control group (P<0.05). The improvement of aesthetic indicators in the observation group after treatment was better than that in the control group (P<0.05). The scores of oral muscle function in the observation group after treatment were higher than those in the control group (P<0.05). Conclusion Combined oral myofunctional training and occlusal guidance therapy can effectively improve the effect of early correction of pediatric malocclusion, as well as the aesthetic indicators and oral myofunction.