Objective To analyze the effect of photorejuvenation combined with medical cold compress patch in the treatment of patients with facial telangiectasia complicated with sensitive skin. Methods A total of 117 patients with facial telangiectasia complicated with sensitive skin admitted to our hospital from April 2022 to April 2025 were selected, and they were divided into the control group (58 patients) and the experimental group (59 patients) by the random number table method. Both groups received photorejuvenation treatment. The control group received ice pack cold compress after treatment, and the experimental group received medical cold compress patch after treatment. The clinical efffcacy, stress symptom improvement, skin barrier function and quality of life were compared between the two groups. Results The total effective rate of the experimental group (93.22%) was higher than that of the control group (79.31%) (P<0.05). The scores of redness, pain and burning sensation in the two groups at 30 minutes after treatment were lower than those immediately after treatment, and those in the experimental group were lower than those in the control group (P<0.05). The transepidermal water loss and stratum corneum hydration in the two groups at 1 month after treatment were better than those before treatment, and those in the experimental group were better than those in the control group (P<0.05). The DLQI scores in the two groups at 1 month after treatment were lower than those before treatment, and those in the experimental group were lower than those in the control group (P<0.05). Conclusion The effect of photorejuvenation combined with medical cold compress patches in the treatment of facial telangiectasia complicated with sensitive skin is good, which can reduce post-treatment stress symptoms such as redness and pain, and improve the patients' skin barrier function and quality of life.