Objective To analyze the inffuencing factors for the formation of non-healing wound in burn patients. Methods A total of 98 burn patients admitted to the Department of Burn and Plastic Surgery, People's Hospital of Ningxia Hui Autonomous Region from January 2023 to December 2024 were selected as the research subjects. Patients with non-healing wound were classiffed into the non-healing group (n=50), and the others into the healing group (n=48). Clinical data of the two groups were collected and compared. Univariate analysis and multivariate analysis were used to explore the influencing factors for the formation of non-healing wounds in burn patients. Results Among the 98 patients, 50 had non-healing wound, accounting for 51.02%. Univariate analysis showed that there were statistically signiffcant differences between the non-healing group and the healing group in terms of smoking, long interval between baths, diabetes mellitus, wound infection, moderate alcohol consumption and regular physical exercise (P<0.05). Binary Logistic regression analysis showed that smoking, long interval between baths, diabetes mellitus and wound infection were independent risk factors for the formation of non-healing wound (P<0.05), while moderate alcohol consumption and regular physical exercise were protective factors for the formation of non-healing wounds (P<0.05). Conclusion The incidence of non-healing wound in burn patients is relatively high, and it is closely related to multiple modiffable factors such as smoking, long interval between baths, diabetes mellitus, wound infection, moderate alcohol consumption and regular physical exercise. Therefore, in clinical practice, it is necessary to strengthen the identiffcation and management of risk factors, and actively advocate a healthy lifestyle to promote wound repair and improve patient prognosis.