Objective To analyze the effect of platelet-rich plasma (PRP) on nasofrontal angle and nasofacial angle in patients undergoing nasal base depression filling. Methods A total of 100 patients who needed nasal base depression filling admitted to our hospital from March 2023 to February 2025 were selected as the research subjects, and they were divided into the control group and the study group by the random number table method, with 50 patients in each group. The control group received traditional autologous fat transplantation, and the study group received PRP assisted autologous fat transplantation. The treatment effect, nasofrontal angle, nasofacial angle, aesthetic effect and complications were compared between the two groups. Results The total effective rate of the study group (96.00%) was higher than that of the control group (82.00%) (P <0.05). The nasofrontal angle and nasofacial angle of the two groups at 6 months after operation were better than those before operation , and those of the study group after operation were better than those of the control group (P <0.05). The excellent and good rate of aesthetic effect in the study group (96.00%) was higher than that in the control group (84.00%) (P <0.05). The incidence of complications in the study group (2.00%) was lower than that in the control group (16.00%) (P <0.05). Conclusion PRP assisted autologous fat transplantation can effectively improve the treatment effect and facial aesthetics of patients undergoing nasal base depression filling, optimize the nasofrontal angle and nasofacial angle, and reduce the incidence of complications.