Objective To explore the effect of medical collagen injectable filling therapy on the improvement of periorbital aging in patients with periorbital aging. Methods A total of 66 patients with periorbital aging admitted to Guanshanhu Kelong Xiaoke Medical Aesthetics Clinic from June 2023 to June 2024 were selected, and they were divided into the control group and the observation group by the random number table method, with 33 patients in each group. The control group received hyaluronic acid injectable filling therapy, and the observation group received medical collagen injectable filling therapy. The periorbital aging improvement, skin health status and satisfaction were compared between the two groups. Results The scores of PSS in the observation group at 3 and 6 months after treatment were lower than those in the control group (P <0.05). The scores of moisture content, fineness and texture in the observation group at 3 and 6 months after treatment were higher than those in the control group (P <0.05). The satisfaction rate of the observation group was 100.00%, which was higher than 81.82% of the control group (P <0.05). Conclusion Compared with hyaluronic acid injectable filling, collagen injection therapy has a good clinical effect in the treatment of periorbital aging. It can effectively improve periorbital aging, enhance skin health status and patient satisfaction, and is a highquality clinical scheme for the treatment of periorbital aging.