Objective To analyze the effect of oral orthodontics combined with implant restoration on occlusal function and aesthetic effect in patients with dentition defect and dentomaxillary deformity. Methods A total of 50 patients with dentition defect and dentomaxillary deformity admitted to Hedong District Xiangyanglou Street Community Health Service Center from April 2023 to April 2025 were selected, and they were divided into the reference group and the study group by the random number table method, with 25 patients in each group. The reference group received implant restoration alone, and the study group received oral orthodontics combined with implant restoration. The occlusal function, aesthetic effect, periodontal indicators, quality of life and complication rate were compared between the two groups. Results At 3 months after treatment, the maximum occlusal force and maximum occlusal contact area of the study group were higher than those in the reference group, and the asymmetry index of occlusal force was lower than that in the reference group (P <0.05). The scores of PES and WES in the study group at 3 months after treatment were higher than those of the reference group (P <0.05). The scores of gingiva, bleeding and plaque index in the study group at 3 months after treatment were lower than those in the reference group (P <0.05). The scores of quality of life in the study group at 3 months after treatment were higher than those in the reference group (P <0.05). The incidence of complications in the study group (0) was lower than that in the reference group (24.00%) (P <0.05). Conclusion Oral orthodontics combined with implant restoration in the treatment of dentition defect with dentomaxillary deformity can effectively improve occlusal function, restore periodontal status, enhance aesthetic effect and quality of life, and has high safety.