The early management of skin injury directly affects the quality of wound healing and scar formation. Due to the continuous exposure of the wound, the traditional dry wound healing method is prone to cause cell dehydration and necrosis, prolonged inflammatory response, and collagen metabolism disorder, which increases the risk of pathological scar formation. In contrast, moist wound healing can effectively promote epithelial cell migration, regulate the inflammatory response process, and optimize collagen synthesis and remodeling by constructing a suitable moist environment, thereby comprehensively improving the quality of wound repair and reducing the incidence of scar. This paper systematically compares the mechanisms of dry and moist wound healing, establishes a dressing selection scheme based on the RYB wound classification system, and formulates individualized dressing application principles in combination with the pathological characteristics of common clinical wounds such as clean surgical incisions, skin abrasions, burns and scalds, radiation dermatitis, venous ulcers and diabetic feet. At the same time, this paper objectively evaluates the clinical advantages and application limitations of moist wound healing, aiming to provide theoretical basis and technical guidance for the standardized practice of wound management.