Objective To explore the effect of whole-course refined nursing on quality of life and nursing satisfaction in patients with dentition defect undergoing oral implantation. Methods A total of 150 patients with dentition defect who received oral implantation in the Stomatology Center of China-Japan Friendship Hospital from July 2023 to February 2025 were selected, and they were divided into the control group and the observation group by the random number table method, with 75 patients in each group. The control group received conventional nursing, and the observation group received whole-course refined nursing. The quality of life, implant success rate, nursing satisfaction, complication rate and compliance were compared between the two groups. Results The OHIP-14 score of the observation group after nursing was lower than that of the control group (P <0.05). The implant success rate of the observation group was 97.33%, which was higher than 89.33% of the control group (P <0.05). The nursing satisfaction rate of the observation group (98.67%) was higher than that of the control group (86.67%) (P <0.05). The incidence of complications in the observation group was lower than that in the control group (P <0.05). The compliance of the observation group was higher than that of the control group (P <0.05). Conclusion Whole-course refined nursing improves the treatment compliance and nursing satisfaction of patients with dentition defect undergoing implantation. It can effectively increase the implant success rate, help to improve the oral health-related quality of life, and further reduce the risk of complications.