Objective To explore the clinical value of facial rotation flap in postoperative repair after maxillofacial tumor resection. Methods A total of 104 patients with maxillofacial tumors admitted to our hospital from May 2021 to May 2024 were selected as the research subjects, and they were divided into the control group and the study group by the random number table method, with 52 patients in each group. The control group was treated with forearm flap repair, and the study group was treated with facial rotation flap repair. The operation related indexes, satisfaction, aesthetic degree, scar severity and complications were compared between the two groups. Results The flap fabrication and anastomosis time, and operation time of the study group were shorter than those of the control group (P <0.05). The satisfaction scores of the nose and bilateral zygomatic buccal regions in the study group were higher than those in the control group (P <0.05). The aesthetic scores of the study group at 1, 3, 6 and 12 months after suture removal were lower than those of the control group (P <0.05). The scores of vascular distribution, thickness, color and softness in the study group were lower than those in the control group (P <0.05). The incidence of complications in the study group (1.92%) was lower than that in the control group (13.46%) (P <0.05). Conclusion The application of facial rotation flap in postoperative repair after maxillofacial tumor resection has a remarkable effect. It can optimize operation related indexes, reduce the incidence of complications, improve the severity of postoperative scars, and enhance the aesthetic degree and patient satisfaction.