Objective To observe the clinical effect of artificial dermis combined with autologous thin split-thickness skin grafting in the treatment of burn contracture scars. Methods From January 2021 to December 2022, 24 patients with burn contracture scars were treated with artificial dermis combined with autologous thin split-thickness skin grafting. All patients underwent artificial dermis implantation after burn contracture scar excision, and after the artificial dermis was well vascularized, autologous thin split-thickness skin grafts were implanted. The postoperative artificial dermis vascularization time, survival rate of grafts 7 days after surgery, wound healing and scar conditions in the recipient area before and after surgery, and the excellent and good rate of ADL scores in the surgical site of the recipient area before and after surgery were observed and recorded. Results In this group of 24 patients, the wounds after scar excision were implanted with artificial dermis in one stage, all of which completed vascularization, with an average vascularization time of (16.57±1.33) days. The survival rate of grafts in the recipient area 7 days after skin grafting was 93.67%±3.33%, indicating excellent survival. The healing time of grafts in the recipient area was (14.67±2.67) days, and the wound healing time in the donor area was (17.67±1.33) days, both of which were normal and complete. The VSS score of scars in the surgical recipient area was (10.18±1.45) at admission, and it was (5.67±1.33) 12 months after surgery, with a statistically significant difference between the two (P<0.05). The excellent and good rate of ADL scores in the surgical site of the recipient area before and after surgery also showed a statistically significant difference (P<0.05). Conclusion The treatment of burn contracture scars with artificial dermis combined with autologous thin split-thickness skin grafting has good clinical effects and is worthy of promotion and application.