Objective To analyze the application effect of nano-silver dressing combined with Moist Exposed Burn Ointment (MEBO) in the moist healing of second-degree burn wounds. Methods A total of 100 patients with second-degree burns admitted to our hospital from January 2022 to January 2025 were selected and divided into groups using a random number table method. The control group (50 cases) received nano-silver dressing treatment, while the study group (50 cases) received combined treatment with nano-silver dressing and MEBO. Both groups were treated until wound healing. Comparisons were made between the two groups regarding inflammatory factor levels [interleukin-6 (IL-6), C-reactive protein (CRP)], wound healing status, growth factor levels [vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)], and scar hyperplasia status [Vancouver Scar Scale (VSS)]. Results The wound healing time and complete eschar separation time in the study group were shorter than those in the control group (P < 0.05). The VSS score at the 3-month follow-up was lower in the study group than in the control group (P < 0.05). At the end of treatment, serum levels of IL-6 and CRP were lower in the study group compared to the control group (P < 0.05). Serum levels of VEGF and bFGF at the end of treatment were higher in the study group than in the control group (P < 0.05). Conclusion The combination of nano-silver dressing and Moist Exposed Burn Ointment can synergistically reduce the early inflammatory response in patients with second-degree burns, elevate growth factor levels at the wound site, accelerate wound healing, effectively improve long-term scar hyperplasia, and contribute to achieving better aesthetic repair outcomes.